Inclusion-Body Myositis: Newest Concepts of Pathogenesis and Relation to Aging and Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis.
PURPOSE OF REVIEW Sporadic inclusion-body myositis, the most common muscle disease of older persons, has no known cause or persistently beneficial treatment. The unfolding pathogenesis could lead to new treatment strategies and it is now of growing interest among clinicians and basic scientists. About 100 papers related to the subject were published in 2006 and the first part of 2007 (we cite o...
متن کاملPathogenesis and therapy of inclusion body myositis.
PURPOSE OF REVIEW Inclusion body myositis (IBM) is a poorly understood progressive muscle disease of middle and later life. Its dual pathologies of autoimmunity and unexplained myofiber degeneration and loss have been enigmatic since its earliest descriptions over 40 years ago. No reliable effective therapy currently exists for IBM. This review provides an update of current issues in the pathog...
متن کاملInclusion body myositis: old and new concepts.
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy occurring in patients over the age of 50 years and probably accounts for about 30% of all inflammatory myopathies. Muscle biopsy characteristically reveals endomysial inflammation, small groups of atrophic fibres, eosinophilic cytoplasmic inclusions and muscle fibres with one or more rimmed vacuoles. However, any ...
متن کاملInclusion body myositis pathogenesis: Steady progress.
Inclusion body myositis (IBM) is a slowly progressive skeletal muscle disease for which no effective pharmacological therapy is available. Since its initial pathological description 50 years ago, substantial progress has been made in our clinical understanding of IBM. We now have extensive understanding of its demographics, pattern of muscle involvement, and diagnostic criteria, and large amoun...
متن کاملInclusion body myositis: new insights into pathogenesis.
PURPOSE OF REVIEW The pathogenesis of sporadic inclusion body myositis is complex and the disease has a relentless course. Recent observations regarding possible mechanisms of disease may provide targets for therapy. RECENT FINDINGS Evidence is strengthening that specific T-cell and B-cell responses are ongoing in skeletal muscle in sporadic inclusion body myositis and that cytokines and chem...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2001
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/60.1.1